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. 1998 Mar 1;54(2):212-8.
doi: 10.1016/s0169-328x(97)00337-9.

Alzheimer-associated presenilin-1 gene is induced in gerbil hippocampus after transient ischemia

H Tanimukai  1 , K Imaizumi, T Kudo, T Katayama, M Tsuda, T Takagi, M Tohyama, M Takeda
Affiliations

Alzheimer-associated presenilin-1 gene is induced in gerbil hippocampus after transient ischemia

H Tanimukai et al. Brain Res Mol Brain Res. .

Abstract

To investigate the biological roles of the presenilin-1 (PS-1) gene after neuronal injury, the changes of PS-1 mRNA expression in the gerbil hippocampus after transient ischemia were examined. From 1 day to 3 day-reperfusion after 5 min-ischemia, PS-1 mRNA was induced in the hippocampus compared with the sham-operated control. The cells which induced the PS-1 genes were neurons of CA3 and dentate gyrus, the region relatively resistant to ischemic stress. These findings suggest that the induction of PS-1 genes may be associated with some responses of neurons damaged by transient ischemia.

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