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. 1998 Mar 1;54(2):321-6.
doi: 10.1016/s0169-328x(97)00353-7.

mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality

H H Loh  1 , H C Liu, A Cavalli, W Yang, Y F Chen, L N Wei
Affiliations

mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality

H H Loh et al. Brain Res Mol Brain Res. .

Abstract

The mu opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of mu-specific opioid ligands and acute morphine lethality are mediated by the mu receptor.

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