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Clinical Trial
. 1998 Apr;42(4):927-9.
doi: 10.1128/AAC.42.4.927.

Effect of grapefruit juice on clarithromycin pharmacokinetics

K L Cheng  1 , A N Nafziger, C A Peloquin, G W Amsden
Affiliations
Clinical Trial

Effect of grapefruit juice on clarithromycin pharmacokinetics

K L Cheng et al. Antimicrob Agents Chemother. 1998 Apr.

Abstract

To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromycin (82 +/- 35 versus 148 +/- 83 min; P = 0.02) and 14-hydroxyclarithromycin (84 +/- 38 min versus 173 +/- 85; P = 0.01) but did not affect other pharmacokinetic parameters.

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