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Clinical Trial
. 1998 Apr;42(4):930-3.
doi: 10.1128/AAC.42.4.930.

Fluconazole pharmacokinetics in burn patients

B A Boucher  1 , S R King, H L Wandschneider, W L Hickerson, S D Hanes, V L Herring, T W Canada, M M Hess
Affiliations
Clinical Trial

Fluconazole pharmacokinetics in burn patients

B A Boucher et al. Antimicrob Agents Chemother. 1998 Apr.

Abstract

The pharmacokinetics of fluconazole in nine adult patients with severe (30 to 95% total body surface area) burns were studied. There was no significant difference in half-life (t1/2), clearance (CL), or volume of distribution (V) over time in five patients on days 3 and 8 of the study (P > 0.05). Combined parameter estimates (means +/- standard deviations) for all nine patients for the two study periods were as follows: t1/2, 24.4 +/- 5.8 h; CL, 0.36 +/- 0.09 ml/min/kg; and V, 0.72 +/- 0.12 liters/kg. These estimates of t1/2 and CL in burn patients were approximately 13% shorter and 30% more rapid, respectively, than the most extreme estimates reported for other populations.

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