Comparative Study
doi: 10.1128/AAC.42.4.934.
Efficacy of sulfamethoxypyridazine in a murine model of Pneumocystis carinii pneumonia
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- PMID: 9559812
- PMCID: PMC105571
- DOI: 10.1128/AAC.42.4.934
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Comparative Study
Efficacy of sulfamethoxypyridazine in a murine model of Pneumocystis carinii pneumonia
Antimicrob Agents Chemother.
1998 Apr.
Abstract
Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects. Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a murine model of P. carinii and might be a candidate for testing in infected patients.
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