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Comparative Study
. 1998 Apr;42(4):934-5.
doi: 10.1128/AAC.42.4.934.

Efficacy of sulfamethoxypyridazine in a murine model of Pneumocystis carinii pneumonia

M S Bartlett  1 , M M Shaw, J W Smith, S R Meshnick
Affiliations
Comparative Study

Efficacy of sulfamethoxypyridazine in a murine model of Pneumocystis carinii pneumonia

M S Bartlett et al. Antimicrob Agents Chemother. 1998 Apr.

Abstract

Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects. Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a murine model of P. carinii and might be a candidate for testing in infected patients.

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