Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Apr;42(4):945-6.
doi: 10.1128/AAC.42.4.945.

Antipneumococcal activities of a ketolide (HMR 3647), a streptogramin (quinupristin-dalfopristin), a macrolide (erythromycin), and a lincosamide (clindamycin)

A L Barry  1 , P C Fuchs, S D Brown
Affiliations

Antipneumococcal activities of a ketolide (HMR 3647), a streptogramin (quinupristin-dalfopristin), a macrolide (erythromycin), and a lincosamide (clindamycin)

A L Barry et al. Antimicrob Agents Chemother. 1998 Apr.

Abstract

Four different compounds belonging to the macrolide-lincosamide-streptogramin B (MLSb) class of antimicrobial agents were tested against 611 Streptococcus pneumoniae strains. The ketolide (HMR 3647, previously RU66647) and the streptogramin (quinupristin-dalfopristin) were both active against pneumococci with high-level MLSb resistance (clindamycin-resistant strains) as well as those with low-level macrolide resistance (clindamycin-susceptible strains).

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Barry A L, Fuchs P C, Brown S D. Macrolide resistance among Streptococcus pneumoniae and Streptococcus pyogenes isolates from outpatients in the USA. J Antimicrob Chemother. 1997;40:139–140. - PubMed
    1. Barry A L, Pfaller M A, Fuchs P C, Packer R R. In vitro activities of 12 orally administered antimicrobial agents against four species of bacterial respiratory tract pathogens from U.S. medical centers in 1992 and 1993. Antimicrob Agents Chemother. 1994;38:2419–2425. - PMC - PubMed
    1. Biedenbach D, Wanger A, Jones R N. Comparative in vitro activity of quinupristin/dalfopristin (RP 59500) tested against penicillin- and macrolide-resistant pneumococci by the E test. J Antimicrob Chemother. 1996;38:553–555. - PubMed
    1. Doern G V, Brueggemann A, Holley H P, Jr, Rauch A M. Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study. Antimicrob Agents Chemother. 1996;40:1208–1213. - PMC - PubMed
    1. Fasola E L, Bajaksouzian S, Appelbaum P C, Jacobs M R. Variation in erythromycin and clindamycin susceptibilities of Streptococcus pneumoniae by four test methods. Antimicrob Agents Chemother. 1997;41:129–134. - PMC - PubMed

Publication types