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. 1998 Apr;42(4):953-5.
doi: 10.1128/AAC.42.4.953.

Determination of activities of levofloxacin, alone and combined with gentamicin, ceftazidime, cefpirome, and meropenem, against 124 strains of Pseudomonas aeruginosa by checkerboard and time-kill methodology

M A Visalli  1 , M R Jacobs, P C Appelbaum
Affiliations

Determination of activities of levofloxacin, alone and combined with gentamicin, ceftazidime, cefpirome, and meropenem, against 124 strains of Pseudomonas aeruginosa by checkerboard and time-kill methodology

M A Visalli et al. Antimicrob Agents Chemother. 1998 Apr.

Abstract

A total of 124 Pseudomonas aeruginosa strains were tested for synergy between levofloxacin and cefpirome, ceftazidime, gentamicin, and meropenem. Checkerboards yielded synergistic fractional inhibitory concentration (FIC) indices (< or =0.5) with 25 of 496 possible combinations. All other FIC indices were >0.5 to 2 (additive or indifferent), with no antagonism. Time-kill studies with 12 strains showed that levofloxacin (0.06 to 0.5 microg/ml) was synergistic with cefpirome, ceftazidime, gentamicin, and meropenem in 10, 9, 4, and 11 strains, respectively.

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References

    1. Bajaksouzian S, Visalli M A, Jacobs M R, Appelbaum P C. Antipneumococcal activities of cefpirome and cefotaxime, alone and in combination with vancomycin and teicoplanin, determined by checkerboard and time-kill methods. Antimicrob Agents Chemother. 1996;40:1973–1976. - PMC - PubMed
    1. Bajaksouzian S, Visalli M A, Jacobs M R, Appelbaum P C. Activities of levofloxacin, ofloxacin, and ciprofloxacin, alone and in combination with amikacin, against acinetobacters as determined by checkerboard and time-kill studies. Antimicrob Agents Chemother. 1997;41:1073–1076. - PMC - PubMed
    1. Burwen D R, Banerjee S N, Gaynes R P the National Nosocomial Infections Surveillance System. Ceftazidime resistance among selected nosocomial gram-negative bacilli in the United States. J Infect Dis. 1994;170:1622–1625. - PubMed
    1. Cappelletty D M, Rybak M J. Comparison of methodologies for synergism testing of drug combinations against resistant strains of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1996;40:677–683. - PMC - PubMed
    1. Cheng A F B, Ling T K W, Lam A W, Fung K S C, Wise R. The antimicrobial activity and β-lactamase stability of cefpirome, a new fourth-generation cephalosporin in comparison with other agents. J Antimicrob Chemother. 1993;31:699–709. - PubMed

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