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. 1998 Apr;42(4):967-70.
doi: 10.1128/AAC.42.4.967.

In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent

Y Niwano  1 , N Kuzuhara, H Kodama, M Yoshida, T Miyazaki, H Yamaguchi
Affiliations

In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent

Y Niwano et al. Antimicrob Agents Chemother. 1998 Apr.

Abstract

In vitro and in vivo antidermatophyte activities of NND-502, a new imidazole antimycotic agent, were compared with those of two existing antifungal agents, lanoconazole and terbinafine. NND-502 exhibited strong in vitro antifungal activity against Trichophyton spp.; its MIC was 1 to 4 times lower than that of lanoconazole or terbinafine. In an in vivo study with a guinea pig model of tinea pedis, 7-day topical treatment with a 0.5% solution of NND-502 (dissolved in polyethylene glycol 400) was more effective than that with a 0.5% solution of either lanoconazole or terbinafine for eradicating fungi from the infected feet. When the duration of treatment was shortened to 3 days, a topical 1% solution of NND-502 achieved a complete mycological cure, while topical 1% solutions of lanoconazole and terbinafine did not.

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Figures

FIG. 1
FIG. 1
Chemical structures of lanoconazole and NND-502.
FIG. 2
FIG. 2
Experimental schedule for study of the therapeutic efficacy of topical treatment with polyethylene glycol 400 solution, NND-502, lanoconazole, and terbinafine in a guinea pig model of tinea pedis.
See this image and copyright information in PMC

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