A new semisynthetic 7alpha-methoxycephalosporin, CS-1170: 7beta-((cyanomethyl)thio)acetamido)-7alpha-methoxy-3-((1-methyl-1H-tetrazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid
- PMID: 956044
- DOI: 10.7164/antibiotics.29.554
A new semisynthetic 7alpha-methoxycephalosporin, CS-1170: 7beta-((cyanomethyl)thio)acetamido)-7alpha-methoxy-3-((1-methyl-1H-tetrazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid
Abstract
The synthesis and antimicrobial activity of a new semisynthetic 7alpha-methoxycephalosporin,7beta [[(cyanomethyl)thiol]acetamidol]-7alpha-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]-methyl]-3-cephem-4-carboxylic acid (CS-1170), are described. This compound shows interesting antibacterial activity when compared to cefoxitin and cephalothin.
Similar articles
-
Synthetic studies on beta-lactam antibiotics. Part 101. Synthesis of 7beta-[2-carboxy-2-(4-hydroxyphenyl)acetamido]-7alpha-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]-methyl]-1-oxa-1-dethia-3-cephem-4-carboxylic acid disodium salt (6059-S) and its related 1-oxacephems.J Med Chem. 1979 Jul;22(7):757-9. doi: 10.1021/jm00193a001. J Med Chem. 1979. PMID: 448673 No abstract available.
-
Diastereomeric 7-ureidoacetyl cephalosporins. II. 7beta [[[(Aminocarbonyl) amino]-2-thienylacetyl] amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl) thio] methyl]-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid.J Antibiot (Tokyo). 1978 Jun;31(6):561-9. doi: 10.7164/antibiotics.31.561. J Antibiot (Tokyo). 1978. PMID: 681237
-
Synthesis and biological activity of a new semisynthetic cephalosporin, CN-92,982.J Antibiot (Tokyo). 1980 Nov;33(11):1352-6. doi: 10.7164/antibiotics.33.1352. J Antibiot (Tokyo). 1980. PMID: 7251474
-
Synthetic cephalosporins. VII. Synthesis and antibacterial activity of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(3-(3-hydroxy-4-pyridon-1-yl)-3- carboxypropoxyimino)acetamido]-3-(1,2,3-thiadiazol-5-yl)-thiomethyl-3- cephem-4-carboxylic acid and its related compounds.Chem Pharm Bull (Tokyo). 1990 Dec;38(12):3476-9. doi: 10.1248/cpb.38.3476. Chem Pharm Bull (Tokyo). 1990. PMID: 2092946
-
A new cephalosporin. SCE-963: 7-[2-(2-aminothiazol-4-yl)-acetamido]-3-[[[1-(2-dimethylaminoethyl)-1h-tetrazol-5-yl]-thio]methyl]ceph-3-em-4-carboxylic acid. Chemistry and structure-activity relationships.J Antibiot (Tokyo). 1978 Dec;31(12):1262-71. doi: 10.7164/antibiotics.31.1262. J Antibiot (Tokyo). 1978. PMID: 367998
Cited by
-
In vitro and in vivo antibacterial activity of T-1982, a new semisynthetic cephamycin antibiotic.Antimicrob Agents Chemother. 1982 Nov;22(5):728-34. doi: 10.1128/AAC.22.5.728. Antimicrob Agents Chemother. 1982. PMID: 6983861 Free PMC article.
-
Pharmacokinetics of intravenous cefmetazole with emphasis on comparison between predicted theoretical levels in tissue and actual skin window fluid levels.Antimicrob Agents Chemother. 1989 Jun;33(6):924-7. doi: 10.1128/AAC.33.6.924. Antimicrob Agents Chemother. 1989. PMID: 2764542 Free PMC article.
-
Penicillin-insensitive incorporation of D-amino acids into cell wall peptidoglycan influences the amount of bound lipoprotein in Escherichia coli.J Bacteriol. 1984 Dec;160(3):889-94. doi: 10.1128/jb.160.3.889-894.1984. J Bacteriol. 1984. PMID: 6389516 Free PMC article.
-
Pharmacokinetics of cefmetazole administered intramuscularly and intravenously to healthy adults.Antimicrob Agents Chemother. 1985 Oct;28(4):544-7. doi: 10.1128/AAC.28.4.544. Antimicrob Agents Chemother. 1985. PMID: 3865631 Free PMC article.
-
Pharmacokinetics and dose proportionality of cefmetazole in healthy young and elderly volunteers.Antimicrob Agents Chemother. 1990 Oct;34(10):1944-8. doi: 10.1128/AAC.34.10.1944. Antimicrob Agents Chemother. 1990. PMID: 2291659 Free PMC article. Clinical Trial.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources