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Review
. 1998 Apr;12(2):385-406.
doi: 10.1016/s0889-8588(05)70518-9.

Langerhans cell histiocytosis research. Past, present, and future

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Review

Langerhans cell histiocytosis research. Past, present, and future

C Nezelof et al. Hematol Oncol Clin North Am. 1998 Apr.

Abstract

This article reviews the various investigative events that led to the endorsement of the term Langerhans cell histiocytosis for the various clinicopathologic conditions previously called Hand-Schüller-Christian disease, Abt-Letterer-Siwe disease, eosinophilic granuloma of bone, and histiocytosis X. The different denominations reflect the changing conceptual approaches to the so-called reticuloendothelial system and the successive acquisition of new ultrastructural and immunocytochemical data.

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