Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1998 May;101(5):865-9.
doi: 10.1542/peds.101.5.865.

Somatosensory evoked potentials in very preterm infants in relation to L-thyroxine supplementation

B J Smit  1 , J H Kok, L S de Vries, A G van Wassenaer, F W Dekker, B W Ongerboer de Visser
Affiliations
Clinical Trial

Somatosensory evoked potentials in very preterm infants in relation to L-thyroxine supplementation

B J Smit et al. Pediatrics. 1998 May.

Abstract

Objective: To study the effect of L-thyroxine supplementation on neurologic maturation in very preterm infants with transient hypothyroxinemia.

Design: Randomized, double-blind, placebo-controlled, L-thyroxine supplementation trial.

Setting: Level III neonatal intensive care unit.

Subjects: A total of 200 infants <30 weeks' gestational age.

Intervention: Subjects were randomly assigned to receive L-thyroxine (8 microg/kg birth weight per day) or a placebo during the first 6 weeks of life.

Methods: Median nerve somatosensory evoked potentials were recorded, measuring cortical N1 peak latency at 2 weeks of age, at term, and at 6 months (corrected) age.

Results: Cortical N1 peak latency was not decreased significantly in the L-thyroxine group compared with the placebo group throughout the study period.

Conclusion: L-Thyroxine supplementation during the first 6 weeks of life did not decrease cortical N1 peak latency in infants of <30 weeks' gestational age.

PubMed Disclaimer

Publication types