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. 1976 Jul;32(1):143-7.
doi: 10.1099/0022-1317-32-1-143.

Suppression of interferon production by vitamin A

J E Blalock, G Gifford

Suppression of interferon production by vitamin A

J E Blalock et al. J Gen Virol. 1976 Jul.

Abstract

Vitamin A (retinoic acid) suppressed interferon production by L cells infected with Newcastle disease virus (NDV). This suppression was maximal when cells were treated with retinoic acid for 2 h after NDV adsorption, indicating that the inhibitory step was an early event. It was not due to inhibition of total RNA synthesis. Retinoic acid treatment caused both a delay in appearance of interferon and a reduced rate of synthesis thereafter.

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