Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Nov 25;120(1):101-8.
doi: 10.1016/s0304-3835(97)00296-6.

Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung

J Yatsunami  1 , N Tsuruta, K Ogata, K Wakamatsu, K Takayama, M Kawasaki, Y Nakanishi, N Hara, S Hayashi
Affiliations

Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung

J Yatsunami et al. Cancer Lett. .

Abstract

We examined interleukin-8 (IL-8) production in 17 lung cancer cell lines, IL-8 expression in tumor specimens and IL-8's contribution to tumor-induced angiogenesis in vivo. Eight of 13 non-small cell lung cancer cell lines constitutively produced high levels of IL-8. Four small cell lung cancer cell lines produced little or no IL-8. Immunohistochemical analysis of transbronchial biopsy specimens revealed IL-8 staining within adenocarcinomas (22/32), squamous cell carcinomas (12/21) and large cell carcinomas (2/3), but not within most small cell carcinomas (1/22). Anti-IL-8 antisera blocked tumor angiogenesis by two IL-8 producing cell lines in a mouse model.

PubMed Disclaimer

MeSH terms

LinkOut - more resources