doi: 10.4269/ajtmh.1998.58.424.
Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: measurement of local host responses
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- PMID: 9574786
- DOI: 10.4269/ajtmh.1998.58.424
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Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: measurement of local host responses
Am J Trop Med Hyg.
1998 Apr.
Abstract
Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-alpha and transforming growth factor-beta. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.
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