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. 1998 Apr;58(4):424-30.
doi: 10.4269/ajtmh.1998.58.424.

Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: measurement of local host responses

L Franco  1 , L Najvar, B L Gomez, S Restrepo, J R Graybill, A Restrepo
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Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: measurement of local host responses

L Franco et al. Am J Trop Med Hyg. 1998 Apr.

Abstract

Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-alpha and transforming growth factor-beta. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.

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