Review
Angiogenic molecules and cancer metastasis
Affiliations
- PMID: 9575423
Item in Clipboard
Review
Angiogenic molecules and cancer metastasis
In Vivo.
1998 Jan-Feb.
Abstract
The progressive growth of primary neoplasms and metastases depends on the development of adequate vasculature, i.e., angiogenesis. The extent of vascularization in different malignancies correlates directly with their metastatic potential and, hence, inversely with the survival of the patient. The induction of neovascularization is mediated by both tumor cells and host cells and the interaction of the two. The balance of positive and negative regulatory molecules released by tumor cells and host cells determines the biological outcome which, in the case of tumor growth, favors angiogenesis.
Similar articles
-
Angiogenesis and cancer metastasis.Cancer J. 2000 Apr;6 Suppl 2:S134-41. Cancer J. 2000. PMID: 10803828 Review.
-
Tumor-associated angiogenesis: mechanisms, clinical implications, and therapeutic strategies.Semin Oncol. 1997 Apr;24(2):203-18. Semin Oncol. 1997. PMID: 9129690 Review.
-
Molecular determinants of angiogenesis in cancer metastasis.Cancer J Sci Am. 1998 May;4 Suppl 1:S58-66. Cancer J Sci Am. 1998. PMID: 9619272 Review. No abstract available.
-
[Tumoral vascularization: physiopathology and therapeutic prospects].Bull Cancer. 1997 Apr;84(4):391-5. Bull Cancer. 1997. PMID: 9238163 Review. French.
-
The clinical implications of angiogenesis in the treatment of cancer.J Med Liban. 2002 Jan-Apr;50(1-2):32-8. J Med Liban. 2002. PMID: 12841311 Review.
Cited by
-
PEG-3, a nontransforming cancer progression gene, is a positive regulator of cancer aggressiveness and angiogenesis.Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15115-20. doi: 10.1073/pnas.96.26.15115. Proc Natl Acad Sci U S A. 1999. PMID: 10611347 Free PMC article.
-
A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours.Br J Cancer. 2006 Mar 13;94(5):654-60. doi: 10.1038/sj.bjc.6602995. Br J Cancer. 2006. PMID: 16495926 Free PMC article.
-
Cyclooxygenase-2 (COX-2) mRNA expression levels in normal lung tissues and non-small cell lung cancers.Jpn J Cancer Res. 1999 Dec;90(12):1338-43. doi: 10.1111/j.1349-7006.1999.tb00717.x. Jpn J Cancer Res. 1999. PMID: 10665651 Free PMC article.
-
Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine.Cancer Res. 2005 Dec 1;65(23):10794-800. doi: 10.1158/0008-5472.CAN-05-0623. Cancer Res. 2005. PMID: 16322225 Free PMC article.
-
Isolation by size of epithelial tumor cells : a new method for the immunomorphological and molecular characterization of circulatingtumor cells.Am J Pathol. 2000 Jan;156(1):57-63. doi: 10.1016/S0002-9440(10)64706-2. Am J Pathol. 2000. PMID: 10623654 Free PMC article.