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Review
. 1998 May;5(5):R105-13.
doi: 10.1016/s1074-5521(98)90616-0.

Stretching exercises--flexibility in dihydrofolate reductase catalysis

G P Miller  1 , S J Benkovic
Affiliations
Review

Stretching exercises--flexibility in dihydrofolate reductase catalysis

G P Miller et al. Chem Biol. 1998 May.

Abstract

As an enzyme, dihydrofolate reductase performs two tasks: transformation of its substrate dihydrofolate or folate to tetrahydrofolate, using NADPH as a cofactor, and regeneration of the enzyme for a subsequent round of catalysis. Studies discussed in this review highlight the role of conformational flexibility in both of these enzymatic functions.

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