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Review
. 1998 May;18(3):149-85.
doi: 10.1002/(sici)1098-1128(199805)18:3<149::aid-med2>3.0.co;2-x.

The search for orally active medications through combinatorial chemistry

R A Fecik  1 , K E Frank, E J Gentry, S R Menon, L A Mitscher, H Telikepalli
Affiliations
Review

The search for orally active medications through combinatorial chemistry

R A Fecik et al. Med Res Rev. 1998 May.

Abstract

The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.

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