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. 1998 Mar 30;9(5):911-3.
doi: 10.1097/00001756-199803300-00027.

BetaAPP gamma-secretase and SREBP site 2 protease are two different enzymes

T Tomita  1 , T Y Chang, T Kodama, T Iwatsubo
Affiliations

BetaAPP gamma-secretase and SREBP site 2 protease are two different enzymes

T Tomita et al. Neuroreport. .

Abstract

The cleavage process of sterol regulatory element binding proteins (SREBPs) shares several characteristics with that of beta-amyloid precursor protein (betaAPP). We studied the secretion of amyloid beta protein (Abeta) from mutant M19 Chinese hamster ovary (CHO) cells that are defective in the site 2 cleavage of SREBPs. The levels as well as the C-terminal properties of Abeta secreted from M19 cells were similar to those from wild-type CHO cells, demonstrating that gamma-cleavage of betaAPP occurs normally in M19 cells. The present data indicated that gamma-secretase of betaAPP and SREBP site 2 protease are distinct enzymes.

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