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. 1998 Apr;64(3):281-2.
doi: 10.1055/s-2006-957429.

Xanthones with antimalarial activity from Garcinia dulcis

K Likhitwitayawuid, W Chanmahasathien, N Ruangrungsi, J Krungkrai

Xanthones with antimalarial activity from Garcinia dulcis

K Likhitwitayawuid et al. Planta Med. 1998 Apr.

Abstract

Chromatographic separation of the EtOH extract of the bark of Garcinia dulcis (Guttiferae) furnished five xanthones, viz 1,7-dihydroxyxanthone (1), 12b-hydroxy-des-D-garcigerrin A (2), 1-O-methylsymphoxanthone (3), symphoxanthone (4), and garciniaxanthone (5). These xanthones 1-5 showed inhibitory effects on the growth of Plasmodium falciparum with IC50 values of 0.96-3.88 micrograms/ml. In addition, revised 13C-NMR assignments of 3 and complete 13C-NMR assignments of 4 were obtained through analysis of their COSY, NOESY, HMQC, and HMBC spectra.

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