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Review
. 1998 Apr 30;392(6679):885-8.
doi: 10.1038/31860.

Allosteric effects of DNA on transcriptional regulators

J A Lefstin  1 , K R Yamamoto
Affiliations
Review

Allosteric effects of DNA on transcriptional regulators

J A Lefstin et al. Nature. .

Abstract

Selective gene transcription is mediated in part by regulatory proteins that bind to DNA response elements. These regulatory proteins receive global information from signal-transduction events. But transcriptional regulators may also be modified in an allosteric manner by response elements themselves to generate the pattern of regulation that is appropriate to an individual gene.

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