Review
doi: 10.1677/joe.0.1560401.
Alternative RNA processing--its role in regulating expression of calcitonin/calcitonin gene-related peptide
Affiliations
- PMID: 9582495
- DOI: 10.1677/joe.0.1560401
Item in Clipboard
Review
Alternative RNA processing--its role in regulating expression of calcitonin/calcitonin gene-related peptide
J Endocrinol.
1998 Mar.
Abstract
The calcitonin/calcitonin gene-related peptide (CT/CGRP) gene is one of the earliest studied examples of alternative RNA processing. The regulatory mechanisms controlling this event are poorly understood. We have identified and characterized an intron element residing in intron 4 of the human CT/CGRP gene. This intron element functions to enhance polyadenylation of an embedded alternative 3'-terminal exon within the CT/CGRP gene and is potentially involved in tissue-specific regulation of CT/CGRP RNA processing.
Similar articles
-
An intron enhancer recognized by splicing factors activates polyadenylation.Genes Dev. 1996 Jan 15;10(2):208-19. doi: 10.1101/gad.10.2.208. Genes Dev. 1996. PMID: 8566754
-
An intron enhancer containing a 5' splice site sequence in the human calcitonin/calcitonin gene-related peptide gene.Mol Cell Biol. 1995 Dec;15(12):7135-42. doi: 10.1128/MCB.15.12.7135. Mol Cell Biol. 1995. PMID: 8524281 Free PMC article.
-
The calcitonin exon and its flanking intronic sequences are sufficient for the regulation of human calcitonin/calcitonin gene-related peptide alternative RNA splicing.Mol Endocrinol. 1994 Dec;8(12):1618-26. doi: 10.1210/mend.8.12.7535892. Mol Endocrinol. 1994. PMID: 7535892
-
Molecular mechanisms of cell-specific and regulated expression of the calcitonin/alpha-CGRP and beta-CGRP genes.Ann N Y Acad Sci. 1992 Jun 30;657:36-49. doi: 10.1111/j.1749-6632.1992.tb22755.x. Ann N Y Acad Sci. 1992. PMID: 1637094 Review.
-
Mechanism of tissue-specific alternative RNA processing of the calcitonin CGRP gene.Front Horm Res. 1999;25:18-33. doi: 10.1159/000061000. Front Horm Res. 1999. PMID: 10941400 Review. No abstract available.
Cited by
-
An ATM homologue from Arabidopsis thaliana: complete genomic organisation and expression analysis.Nucleic Acids Res. 2000 Apr 15;28(8):1692-9. doi: 10.1093/nar/28.8.1692. Nucleic Acids Res. 2000. PMID: 10734187 Free PMC article.
-
Human IL12RB1 expression is allele-biased and produces a novel IL12 response regulator.Genes Immun. 2019 Mar;20(3):181-197. doi: 10.1038/s41435-018-0023-2. Epub 2018 Mar 30. Genes Immun. 2019. PMID: 29599514 Free PMC article.
-
Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing.Mol Cell Biol. 2007 Feb;27(3):830-41. doi: 10.1128/MCB.01015-06. Epub 2006 Nov 13. Mol Cell Biol. 2007. PMID: 17101796 Free PMC article.
-
High-throughput alternative splicing quantification by primer extension and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Nucleic Acids Res. 2005 Jun 20;33(11):e99. doi: 10.1093/nar/gni098. Nucleic Acids Res. 2005. PMID: 15967806 Free PMC article.
-
Calcitonin gene-related peptide: physiology and pathophysiology.Physiol Rev. 2014 Oct;94(4):1099-142. doi: 10.1152/physrev.00034.2013. Physiol Rev. 2014. PMID: 25287861 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
