Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1998 May;43(5):673-6.
doi: 10.1002/ana.410430519.

Neuropathology of preclinical and clinical late-onset Alzheimer's disease

J C Troncoso  1 , A M Cataldo, R A Nixon, J L Barnett, M K Lee, F Checler, D R Fowler, J E Smialek, B Crain, L J Martin, C H Kawas
Affiliations
Free article
Case Reports

Neuropathology of preclinical and clinical late-onset Alzheimer's disease

J C Troncoso et al. Ann Neurol. 1998 May.
Free article

Abstract

We report on the neuropathological examinations of a 74-year-old woman with Alzheimer's disease (AD) and of her 47-year-old nondemented daughter. The brain of the mother showed fully developed pathological changes of AD. By contrast, the brain of the daughter revealed only perineuronal deposition of diffuse amyloid in cerebral cortex and striking abnormalities of the endosomal-lysosomal system, without neurofibrillary, glial, or microglial changes. These observations suggest that amyloid deposition and endosomal-lysosomal changes are early events in late-onset AD and that they may precede the onset of dementia by several decades.

PubMed Disclaimer

Publication types