Oligonucleotide synthesis by the use of a 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBZ) group for the 5'-hydroxyl group of ribonucleoside and 2'-deoxyribonucleoside 3'-phosphoramidites
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- PMID: 9585991
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Oligonucleotide synthesis by the use of a 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBZ) group for the 5'-hydroxyl group of ribonucleoside and 2'-deoxyribonucleoside 3'-phosphoramidites
Nucleic Acids Symp Ser.
1997.
Abstract
Synthetic studies on the CpCpA terminus triplet, whose exocyclic amino groups are all labeled with 15N, and a phosphorodithioate-linked oligonucleotide in terms of 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) group as the novel base-labile protecting group for the 5'-hydroxyl groups of nucleoside 3'-phosphoramidites, are described.
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