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. 1997:(37):305-6.

Aminoacyl-tRNA synthesis in Archaea

M Ibba  1 , I Celic, A Curnow, H Kim, J Pelaschier, D Tumbula, U Vothknecht, C Woese, D Söll
Affiliations
  • PMID: 9586121

Aminoacyl-tRNA synthesis in Archaea

M Ibba et al. Nucleic Acids Symp Ser. 1997.

Abstract

The mechanism of aminoacyl-tRNA synthesis differs substantially between Archaea, Bacteria and Eukarya. Sequencing of archaeal genomes has suggested that the asparaginyl-, cysteinyl-, glutaminyl- and lysyl-tRNA synthetases are absent from a number of organisms in this kingdom. The absence of the asparaginyl- and glutaminyl-tRNA synthetases is in agreement with the observation that Asn-tRNA and Gln-tRNA are synthesized by tRNA-dependent transamidation of Asp-tRNA and Glu-tRNA respectively in the archaeon Haloferax volcanii. Biochemical and genetic studies have now shown that while the cysteinyl- and lysyl-tRNA synthetases are present, the enzymes responsible for these activities are unique to Archaea.

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