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Review
. 1998 Apr;6(4):154-9.
doi: 10.1016/s0966-842x(98)01230-x.

Antibacterial and anti-inflammatory agents that target endotoxin

T J Wyckoff  1 , C R Raetz, J E Jackman
Affiliations
Review

Antibacterial and anti-inflammatory agents that target endotoxin

T J Wyckoff et al. Trends Microbiol. 1998 Apr.

Abstract

Antibiotic-resistant bacterial infections are a major clinical problem. Lipid A, the active part of lipopolysaccharide endotoxins in Gram-negative bacteria, is an intriguing target for new antibacterial and anti-inflammatory agents. Inhibition of lipid A biosynthesis kills most Gram-negative bacteria, increases bacterial permeability to antibiotics and decreases endotoxin production.

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