[Preservation of hematopoietic stem cells by slow freezing and elimination of the heat of fusion]
[Article in
French]
- PMID: 95897
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[Preservation of hematopoietic stem cells by slow freezing and elimination of the heat of fusion]
[Article in
French]
C R Acad Hebd Seances Acad Sci D.
.
Abstract
Previous experiments, in dogs with fresh bone marrow or bone marrow frozen with a modified freezing system have demonstrated a 100% recovery of frozen stem cells, stored for periods up to 5 months. Five patients, three with drug resistant acute leukemia and two with metastic carcinomas, have been treated with a high dose combination chemotherapy regimen (TACC) followed by reinfusion of marrow cryopreserved with the same modified freezing system. Following the reinfusion of marrow, autologous engraftment was demonstrated on bone marrow aspiration between days 5 and 10.
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