[Comparison of various types of imidazole derivatives for treatment of filamentous fungal keratitis]

Abstract

Objective: 73 eyes of 73 patients with filamentous fungal keratitis were treated by various types of imidazole derivatives.

Methods: The mean patient age was 36 (range, 15-62) years. The areas of corneal ulcer were 2-4 mm x 2-5 mm. The hypopyon was 1-3 mm in height. The patients were randomly divided into 4 groups: I 23 eyes were treated by 1% miconazole suspension. II 15 eyes by imidazole mixed oil (i.e. econazole and miconazole in castor oil). III 19 eyes by dusting mixed imidazole powder onto focal corneal lesions. IV 16 eyes by focal corneal lesion resection combined with dusting mixed imidazole powder.

Results: The cure rates were 21.74%, 66.67%, 73.68% and 93.75%, and the average days of treatment were 65, 68, 35 and 19, respectively, in the 4 groups. The differences in the cure rates and in the means of treatment durations between each of the former three groups and the 4th group are remarkable (P <0.01).

Conclusion: Focal corneal lesion resection combined with dusting mixed imidazole powder is relatively effective in treatment of filamentous fungal keratitis.