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Case Reports
. 1976 May;52(607):305-8.
doi: 10.1136/pgmj.52.607.305.

Combination antifungal therapy for cryptococcal meningitis

J S Tobias, P F Wrigley, E Shaw
Case Reports

Combination antifungal therapy for cryptococcal meningitis

J S Tobias et al. Postgrad Med J. 1976 May.

Abstract

Two patients with Hodgkin's disease and cryptococcal meningitis are described. Both patients were treated with a combination of the two antifungal agents, amphotericin B and flucytosine. Nephrotoxicity was easily reversible in both patients and clinical improvement was seen with this combination therapy. Intrathecal therapy with amphotericin B was used in both patients. The optimal treatment of this disease may prove to be a combination of oral flucytosine, with amphotericin B given by intrathecal injection as well as rapid low dose intravenous injection.

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