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. 1998 May;42(5):1284-7.
doi: 10.1128/AAC.42.5.1284.

Antibacterial activities and inhibitory effects of sitafloxacin (DU-6859a) and its optical isomers against type II topoisomerases

T Akasaka  1 , S Kurosaka, Y Uchida, M Tanaka, K Sato, I Hayakawa
Affiliations

Antibacterial activities and inhibitory effects of sitafloxacin (DU-6859a) and its optical isomers against type II topoisomerases

T Akasaka et al. Antimicrob Agents Chemother. 1998 May.

Abstract

The in vitro inhibitory effects of sitafloxacin (DU-6859a) and its three stereoisomers on bacterial DNA gyrase from Escherichia coli, topoisomerase IV from Staphylococcus aureus, and topoisomerase II from human placenta were compared. No correlation was observed between the inhibitory activities of quinolones against bacterial type II topoisomerases and those against human topoisomerase II. Sitafloxacin showed the most potent inhibitory activities against bacterial type II topoisomerases and the lowest activity against human type II topoisomerase.

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Figures

FIG. 1
FIG. 1
Structures of sitafloxacin and its stereoisomers.
See this image and copyright information in PMC

References

    1. Akahane K, Hoshino K, Sato K, Kimura Y, Une T, Osada Y. Inhibitory effects of quinolones on murine hematopoietic progenitor cells and eukaryotic topoisomerase II. Chemotherapy (Tokyo) 1991;37:224–226. - PubMed
    1. Atarashi S, Imamura M, Kimura Y, Yoshida A, Hayakawa I. Fluorocyclopropyl quinolones. 1. Synthesis and structure-activity relationships of 1-(2-fluorocyclopropyl)-3-pyridonecarboxylic acid antibacterial agents. J Med Chem. 1993;36:3444–3448. - PubMed
    1. Belland R J, Morrison S G, Ison C, Huang W M. Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates. Mol Microbiol. 1994;14:371–380. - PubMed
    1. Drlica K. Biology of bacterial deoxyribonucleic acid topoisomerases. Microbiol Rev. 1984;48:273–289. - PMC - PubMed
    1. Ferrero L, Cameron B, Crouzet J. Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus. Antimicrob Agents Chemother. 1995;39:1554–1558. - PMC - PubMed

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