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Clinical Trial
. 1998 May;42(5):1293-4.
doi: 10.1128/AAC.42.5.1293.

Prophylaxis of Plasmodium falciparum infection in a human challenge model with WR 238605, a new 8-aminoquinoline antimalarial

R P Brueckner  1 , T Coster, D L Wesche, M Shmuklarsky, B G Schuster
Affiliations
Clinical Trial

Prophylaxis of Plasmodium falciparum infection in a human challenge model with WR 238605, a new 8-aminoquinoline antimalarial

R P Brueckner et al. Antimicrob Agents Chemother. 1998 May.

Abstract

The prophylactic efficacy of WR 238605, a primaquine analog, was studied with a human Plasmodium falciparum challenge model. A single oral dose of 600 mg, administered 1 day prior to challenge, successfully protected three of four subjects. The fourth subject developed mild, oligosymptomatic malaria on day 31, with drug concentrations one-half of those in the protected individuals. WR 238605 appears to be a promising prophylactic drug for P. falciparum malaria.

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Figures

FIG. 1
FIG. 1
Structures of WR 238605 and primaquine.
See this image and copyright information in PMC

References

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