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. 1998 May;42(5):1295-7.
doi: 10.1128/AAC.42.5.1295.

Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

G J Alangaden  1 , B N Kreiswirth, A Aouad, M Khetarpal, F R Igno, S L Moghazeh, E K Manavathu, S A Lerner
Affiliations

Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

G J Alangaden et al. Antimicrob Agents Chemother. 1998 May.

Abstract

An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 microg/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

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References

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