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Comparative Study
. 1998 Mar;76(3):317-9.
doi: 10.1254/jjp.76.317.

Effect of tazarotene, an acetylenic retinoid, on human dermal fibroblast

A Ogawa  1 , M Maeguchi, Y Uchida, T Yoshioka, M Kawashima, T Muraki
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Free article
Comparative Study

Effect of tazarotene, an acetylenic retinoid, on human dermal fibroblast

A Ogawa et al. Jpn J Pharmacol. 1998 Mar.
Free article

Abstract

The inhibitory effect of tazarotene, an acetylenic retinoid, on human dermal fibroblast in vitro was compared to that of all-trans-retinoic acid. The proliferation of fibroblasts was inhibited by both retinoids at the concentration of 1 microM after 5 days of culture. Synthesis of DNA and collagen was inhibited by both retinoids concentration-dependently up to 10 microM, although tazarotene was weaker in the inhibition of collagen synthesis. These results suggest the possible usefulness of tazarotene in the treatment of fibrotic diseases.

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