Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1998 Jun;66(6):2401-9.
doi: 10.1128/IAI.66.6.2401-2409.1998.

Bacterial perturbation of cytokine networks

M Wilson  1 , R Seymour, B Henderson
Affiliations
Review

Bacterial perturbation of cytokine networks

M Wilson et al. Infect Immun. 1998 Jun.
No abstract available

PubMed Disclaimer

Figures

FIG. 1
FIG. 1
Interrelationship between Th1 and Th2 CD4 T lymphocytes and the networks of cytokines that they produce. Th1 lymphocyte responses are largely aimed at intracellular parasites in macrophages. Th2 responses are aimed at activating mast cells and eosinophils for anti-helminth defenses. The cytokines produced by both sets of T cells can have inflammatory actions and can also inhibit the actions of the opposite cell type. Thus, IL-10 can block the actions of Th1 lymphocytes. The key question still requiring an answer is the role that microbial products play in determining the nature of CD4 T-lymphocyte cytokine networks and thus in determining the quality and quantity of Th1 and Th2 responses.
See this image and copyright information in PMC

References

    1. Agace W, Hedges S, Andersson U, Anderson J, Ceska M, Svanborg C. Selective cytokine production by epithelial cells following exposure to Escherichia coli. Infect Immun. 1993;61:602–609. - PMC - PubMed
    1. Bermudez L E, Petrofsky M, Shelton K. Epidermal growth factor-binding protein in Mycobacterium avium and Mycobacterium tuberculosis: a possible role in the mechanism of infection. Infect Immun. 1996;64:2917–2922. - PMC - PubMed
    1. Beuscher H U, Rodel F, Forsberg A, Rollinghoff M. Bacterial evasion of host immune defense: Yersinia enterocolitica encodes a suppressor for tumor necrosis factor alpha expression. Infect Immun. 1995;63:1270–1277. - PMC - PubMed
    1. Bogdan C, Gessner A, Röllinghoff M. Cytokines in leishmaniasis: a complex network of stimulatory and inhibitory interactions. Immunobiology. 1993;189:356–396. - PubMed
    1. Byrd T F. Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes. Iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes. J Clin Invest. 1997;99:2518–2529. - PMC - PubMed

Publication types

MeSH terms