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. 1998 Feb;44(3-4):211-4.

Suppression of HIV-1 replication in peripheral blood mononuclear cells by fasudil

H Akari  1 , Y Yamamoto, H Hiwada, Y Saito, N Takayanagi, A H Koyama, A Adachi
Affiliations
  • PMID: 9597811

Suppression of HIV-1 replication in peripheral blood mononuclear cells by fasudil

H Akari et al. J Med Invest. 1998 Feb.

Abstract

Fasudil is a potent inhibitor for various protein kinases such as myosin light chain kinase and protein kinase C. It has been used as a drug for improvement of intracranial vasospasm and following ischaemic diseases. In this report, we demonstrate that fasudil suppressed the replication of human immunodeficiency virus type 1 (HIV-1) in mitogen-activated peripheral blood mononuclear cells. Our finding shows that fasudil may be useful as a new and distinct chemotherapeutic agent against HIV-1 infection.

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