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. 1998 May;25(5):1000-2.

Immunogenetic studies in families of children with juvenile dermatomyositis

A M Reed  1 , L M Pachman, J Hayford, C Ober
Affiliations
  • PMID: 9598907

Immunogenetic studies in families of children with juvenile dermatomyositis

A M Reed et al. J Rheumatol. 1998 May.

Abstract

Objective: We reported an association between juvenile dermatomyositis (JDMS) and the HLA-DQA1*0501 allele. The purpose of this study was to determine whether there is evidence for linkage between JDMS and the DQA1*0501 allele in JDMS families.

Methods: The study population included 18 unrelated patients with JDMS, their parents, and 49 unaffected siblings. Using molecular genetic techniques, we studied the HLA genes, DRB1, DQA1, and tumor necrosis factor-alpha.

Results: Using the transmission disequilibrium test, we confirmed our earlier observations that the HLA-DQA1*0501 allele confers primary susceptibility to JDMS.

Conclusion: DQA1*0501 confers genetic risk for JDMS; we cannot exclude the effects of alleles at other linked loci that were not studied or interactive effects between DQA1 alleles and alleles at other loci.

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