[Various biochemical determinants and radioresistance markers in the mammalian body]

Abstract

The authors data about the relationship between the organism radioresistance (survival/lethality after lethal doses of irradiation) and RNA/DNA ratio, DNA repair activity in blood cells (that damaged with chemical mutagen, UV- and gamma-rays) and also with oxygen radical forms generation in mononuclear and polymorphonuclear blood leucocytes for allogen molecules and bodies inactivation were resumed. Significance of considered correlation was higher after leucocyte mobilization by bacterial lipopolysaccharide injection. The founded relationship between the biochemical processes and survival (radioresistance) was confirmed on the animal radioresistance/radiosensitivity model, when one give to animals the substances in radioprotective effective or not effective doses. The chromatin expression level and the activity of oxygen radical forms generation systems were considered as the biochemical determinants of radioresistance, and their values--as the markers of this status.