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Review
. 1998:214:87-99; discussion 99-103.
doi: 10.1002/9780470515501.ch6.

Multiple epigenetic events regulate mating-type switching of fission yeast

Affiliations
Review

Multiple epigenetic events regulate mating-type switching of fission yeast

A J Klar et al. Novartis Found Symp. 1998.

Abstract

Two epigenetic events at mat1, one of which is DNA strand specific, are required to initiate recombination during mating-type switching. The third, a chromosomally borne imprinted event at the mat2/3 interval regulates silencing and directionality of switching, and prohibits interchromosomal recombination. We speculate that the unit of inheritance in the mat2/3 interval is both DNA plus its associated chromatin structure. Such a control is likely to be essential in maintaining particular states of gene expression during development.

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