The alpha beta versus gamma delta T-cell lineage choice

Abstract

During thymic development, immature T cells rearrange and express the genes encoding the T-cell antigen receptor and mature as either alpha beta or gamma delta lineage T cells. In the past year, advances have been made in understanding the role of individual components of the T-cell antigen receptor complex in the development of alpha beta and gamma delta lineage T cells. In addition, the transmembrane receptor Notch has recently been implicated as a new player in alpha beta versus gamma delta lineage determination.