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. 1998 May 29;280(5368):1432-5.
doi: 10.1126/science.280.5368.1432.

Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

F Altare  1 , A Durandy, D Lammas, J F Emile, S Lamhamedi, F Le Deist, P Drysdale, E Jouanguy, R Döffinger, F Bernaudin, O Jeppsson, J A Gollob, E Meinl, A W Segal, A Fischer, D Kumararatne, J L Casanova
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Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

F Altare et al. Science. .

Abstract

In humans, interferon gamma (IFN-gamma) receptor deficiency leads to a predisposition to mycobacterial infections and impairs the formation of mature granulomas. Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections. Mature granulomas were seen, surrounded by T cells and centered with epithelioid and multinucleated giant cells, yet reduced IFN-gamma concentrations were found to be secreted by activated natural killer and T cells. Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion.

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