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. 1998 May;5(3):319-21.
doi: 10.1128/CDLI.5.3.319-321.1998.

Association of low concentrations of serum mannose-binding protein with recurrent infections in adults

V N Kakkanaiah  1 , G Q Shen, E A Ojo-Amaize, J B Peter
Affiliations

Association of low concentrations of serum mannose-binding protein with recurrent infections in adults

V N Kakkanaiah et al. Clin Diagn Lab Immunol. 1998 May.

Abstract

Low concentrations of mannose-binding protein (MBP; also known as mannose-binding lectin) are associated with common opsonic defect in immunodeficient children. We compared the concentrations of MBP in the sera of 47 adults with non-human immunodeficiency virus-related recurrent infections (group I) and 50 healthy adult controls. Mean serum MBP concentrations in the patient group did not differ significantly from those in the control group (P < 0.4). Nevertheless, the proportion of individuals with less than 5 ng of serum MBP per ml was significantly larger in the patient group (21%, P = 0.01) than in the control group (4%). Group II consisted of 73 pediatric and 56 adult patients with recurrent infections. Pediatric patients had significantly lower mean concentrations of serum MBP than their controls (P < 0.005), and there was no significant difference between the concentrations in sera of adult patients and adult controls (P < 0.4). Again, the proportion of individuals with less than 5 ng of serum MBP per ml was significantly larger in both pediatric (22%, P = 0.045) and adult (38%, P = 0.000016) patients than in their respective controls (4%). Our results demonstrate that, as in children, low concentrations of serum MBP can be associated with recurrent infections in adults.

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Figures

FIG. 1
FIG. 1
Serum MBP concentrations in adult patients with recurrent infections. MBP concentrations were determined by the enzyme immunoassay method as described in Materials and Methods. Open circles represent the mean values, and the dotted line indicates the cutoff value.
FIG. 2
FIG. 2
Serum MBP concentrations in pediatric and adult patients with recurrent infections. Serum samples from pediatric and adult patients with suspected immunodeficiency were screened for MBP as described in Materials and Methods. Open circles represent the mean values, and the dotted line indicates the cutoff value.
See this image and copyright information in PMC

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