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Review
. 1998 Apr;14(4):355-65.
doi: 10.1006/meth.1998.0591.

Use of FLP/FRT system to study Drosophila development

N A Theodosiou  1 , T Xu
Affiliations
Free article
Review

Use of FLP/FRT system to study Drosophila development

N A Theodosiou et al. Methods. 1998 Apr.
Free article

Abstract

Marked clones in mosaic animals have been used extensively to answer developmental questions in Drosophila. Recently, the use of the FLP/FRT system has allowed for the high-frequency production of mosaic animals for 95% of Drosophila genes. Cell markers have been engineered in this system to label mutant clones in both developing tissues and adult cuticle. Strains carrying these genetically marked FLP/FRT chromosomes have greatly enhanced our ability to study gene function in both germline and somatic Drosophila cells.

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