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Review
. 1998 Apr;8(2):173-8.
doi: 10.1016/s0959-437x(98)80138-x.

Covalent modifications of histones: expression from chromatin templates

J R Davie  1
Affiliations
Review

Covalent modifications of histones: expression from chromatin templates

J R Davie. Curr Opin Genet Dev. 1998 Apr.

Abstract

Recent advances highlight the involvement of histone acetyltransferases in transcriptional activation and histone deacetylases in transcriptional repression. Transcription factors loaded onto regulatory DNA elements may recruit either coactivators with histone acetyltransferase activity or corepressors associated with histone deacetylases. The recruited enzymes may either acetylate or deacetylate proximal nucleosomal histones or nonhistone chromosomal proteins.

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