Review
doi: 10.1007/s000180050163.
X-ray studies of enzymes that interact with penicillins
Affiliations
- PMID: 9614972
- PMCID: PMC11147238
- DOI: 10.1007/s000180050163
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Review
X-ray studies of enzymes that interact with penicillins
Cell Mol Life Sci.
1998 Apr.
Abstract
The technique of X-ray diffraction has been successfully applied to enzymes associated with peptidoglycan biosynthesis. The technique has taught us a great deal about the structures and catalytic mechanisms of penicillin-binding proteins and beta-lactamases. An insight into the structural basis for antibiotic resistance is given.
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