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Review
. 1998 Apr;54(4):353-8.
doi: 10.1007/s000180050163.

X-ray studies of enzymes that interact with penicillins

J A Kelly  1 , A P Kuzin, P Charlier, E Fonzé
Affiliations
Review

X-ray studies of enzymes that interact with penicillins

J A Kelly et al. Cell Mol Life Sci. 1998 Apr.

Abstract

The technique of X-ray diffraction has been successfully applied to enzymes associated with peptidoglycan biosynthesis. The technique has taught us a great deal about the structures and catalytic mechanisms of penicillin-binding proteins and beta-lactamases. An insight into the structural basis for antibiotic resistance is given.

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