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Review
. 1997 Dec 19:835:234-49.
doi: 10.1111/j.1749-6632.1997.tb48634.x.

A model of perinatal hypoxic-ischemic brain damage

R C Vannucci  1 , S J Vannucci
Affiliations
Review

A model of perinatal hypoxic-ischemic brain damage

R C Vannucci et al. Ann N Y Acad Sci. .

Abstract

In conclusion, our immature rat model has gained wide acceptance as the animal model of choice to study basic physiologic, biochemical, and molecular mechanisms of perinatal hypoxic-ischemic brain damage. In addition, the model has been used extensively to study those physiologic and therapeutic variables which either are deleterious or beneficial to the perinatal brain undergoing hypoxia-ischemia. As therapeutic interventions are tested in the animal setting, the results will provide important information regarding the effect of these agents in the human setting.

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