Defective human T-cell lymphotropic virus type I (HTLV-I) provirus in 10 Chilean seronegative patients with tropical spastic paraparesis or HTLV-I-associated myelopathy
- PMID: 9620431
- PMCID: PMC104931
- DOI: 10.1128/JCM.36.6.1811-1813.1998
Defective human T-cell lymphotropic virus type I (HTLV-I) provirus in 10 Chilean seronegative patients with tropical spastic paraparesis or HTLV-I-associated myelopathy
Abstract
We studied the presence of tax and ltr genes from human T-cell lymphotropic virus type I (HTLV-I) provirus in the peripheral blood mononuclear cells from 15 seronegative patients with tropical spastic paraparesis or HTLV-I-associated myelopathy by PCR. Only a region of the tax gene from 10 patients was amplified. The nucleotide homologies of six Chilean isolates to the ATK-1 clone ranged between 98.7 and 99.4%.
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References
-
- Cartier L, Araya F, Castillo J L, Ruiz F, Gormaz A, Tajima K. Progressive spastic paraparesis associated with human T-cell leukemia virus type I (HTLV-I) Intern Med. 1992;31:1257–1261. - PubMed
-
- Cartier L, Araya F, Castillo J L, Verdugo R, Mora C, Gajdusek D C, Gibbs C. HTLV-I in Chile: a study of 140 neurological patients. Rev Med Chile. 1990;118:622–628. - PubMed
-
- De B K, Lairmore M D, Griffis K, Williams L J, Villinger F, Quinn T C, Brown C, Nzilambi N, Sugimoto M, Araki S, Folks T M. Comparative analysis of nucleotide sequences of the partial envelope gene (5′ domain) among human T lymphotropic virus type I (HTLV-I) isolates. Virology. 1991;182:413–419. - PubMed
-
- Ehrlich G, Greenberg S, Abbott M. Detection of human T-cell lymphoma/leukemia viruses. In: Innis M, Gelfand D, Sninsky J, White T, editors. PCR protocols: a guide to methods and applications. San Diego, Calif: Academic Press, Inc.; 1990. pp. 325–336.
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