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Comparative Study
. 1998 Mar-Apr;61(2):60-4.

[The complement-activating action of modern x-ray contrast agents]

[Article in Russian]
Iu K Napolov  1 , E N Bolotova, N L Shimanovskiĭ
Affiliations
  • PMID: 9621179
Comparative Study

[The complement-activating action of modern x-ray contrast agents]

[Article in Russian]
Iu K Napolov et al. Eksp Klin Farmakol. 1998 Mar-Apr.

Abstract

The study conducted proved that triombrast (dose dependently) > hexabrics > Ultravist > or = melitrast = omnipac in a concentration interval of 0.03-30.0 mg iodine/ml in vitro and in a dose interval of 0.5-2.0 g iodine/kg in vivo activate the complement system (CS) according to the alternative way in the blood of "sensitive" rats. The degree of CS activation by radiopaque agents (ROA) is significantly determined mathematically by their viscosity and relation of the number of iodine atoms to the number of ions or dissolved particles, and by their hydrophilic (for nonion CS) and osmotic (for ion monomeric CS) properties.

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