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. 1998 Jun 12;280(5370):1750-2.
doi: 10.1126/science.280.5370.1750.

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

H M Shen  1 , A Peters, B Baron, X Zhu, U Storb
Affiliations

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

H M Shen et al. Science. .

Abstract

Immunoglobulin (Ig) genes are hypermutated in B lymphocytes that are the precursors to memory B cells. The mutations are linked to transcription initiation, but non-Ig promoters are permissible for the mutation process; thus, other genes expressed in mutating B cells may also be subject to somatic hypermutation. Significant mutations were not observed in c-MYC, S14, or alpha-fetoprotein (AFP) genes, but BCL-6 was highly mutated in a large proportion of memory B cells of normal individuals. The mutation pattern was similar to that of Ig genes.

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