Can reactive airways dysfunction syndrome (RADS) transform into occupational asthma due to "sensitisation" to isocyanates?
- PMID: 9624303
- PMCID: PMC1758718
- DOI: 10.1136/thx.53.2.152
Can reactive airways dysfunction syndrome (RADS) transform into occupational asthma due to "sensitisation" to isocyanates?
Abstract
The case history is described of a worker who presented with a history suggestive of reactive airways dysfunction syndrome which occurred after an acute high level inhalation of diphenylmethane diisocyanate. Further exposure at work, at a time when concentrations of isocyanates were no longer "irritant", suggested occupational asthma; this diagnosis was confirmed by a specific inhalation challenge test.
Similar articles
-
Occupational asthma (OA) with sensitization to diphenylmethane diisocyanate (MDI) presenting at the onset like a reactive airways dysfunction syndrome (RADS).Am J Ind Med. 2003 Sep;44(3):325-8. doi: 10.1002/ajim.10262. Am J Ind Med. 2003. PMID: 12929154
-
Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject.Respiration. 1997;64(1):111-3. doi: 10.1159/000196653. Respiration. 1997. PMID: 9044486 Review.
-
Asthma-like symptoms in wood product plant workers exposed to methylene diphenyl diisocyanate.Chest. 2000 Oct;118(4):1183-93. doi: 10.1378/chest.118.4.1183. Chest. 2000. PMID: 11035694
-
[The real value of diagnostic methods in case of long time of cessation of occupational exposure to diisocyanates among patients diagnosed in the nofer institute of occupational medicine in Łodź].Med Pr. 2011;62(6):567-77. Med Pr. 2011. PMID: 22312948 Polish.
-
Current diagnostic methods for diisocyanate induced occupational asthma.Am J Ind Med. 1999 Oct;36(4):459-68. doi: 10.1002/(sici)1097-0274(199910)36:4<459::aid-ajim7>3.0.co;2-w. Am J Ind Med. 1999. PMID: 10470011 Review.
Cited by
-
Mass spectrometry-based analysis of murine bronchoalveolar lavage fluid following respiratory exposure to 4,4'-methylene diphenyl diisocyanate aerosol.Xenobiotica. 2018 Jun;48(6):626-636. doi: 10.1080/00498254.2017.1344791. Epub 2017 Jul 21. Xenobiotica. 2018. PMID: 28629263 Free PMC article.
-
Analysis of the interrelationship of the pulmonary irritation and elicitation thresholds in rats sensitized with 1,6-hexamethylene diisocyanate (HDI).Inhal Toxicol. 2015 Mar;27(4):191-206. doi: 10.3109/08958378.2015.1026619. Epub 2015 Apr 29. Inhal Toxicol. 2015. PMID: 25924102 Free PMC article.
-
Reaction products of hexamethylene diisocyanate vapors with "self" molecules in the airways of rabbits exposed via tracheostomy.Xenobiotica. 2018 May;48(5):488-497. doi: 10.1080/00498254.2017.1329569. Epub 2017 Jun 1. Xenobiotica. 2018. PMID: 28489470 Free PMC article.
-
Importance of thorough examination in foreign body exposure: An impressive case of asphyxiation with foam sealant.Clin Case Rep. 2020 Sep 29;8(12):3164-3167. doi: 10.1002/ccr3.3265. eCollection 2020 Dec. Clin Case Rep. 2020. PMID: 33363900 Free PMC article.