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Comparative Study
. 1976;51(1-2):151-5.
doi: 10.1007/BF01317844.

Effects of splenectomy on production of poly I:C induced serum interferon in rabbits

M Nain, H Kohlhage
Comparative Study

Effects of splenectomy on production of poly I:C induced serum interferon in rabbits

M Nain et al. Arch Virol. 1976.

Abstract

Splenectomy in rabbits causes a temporary reduction in interferon responding capacity of Poly I:C, followed by a period of hyperreactivity. At the same time a fraction of interferon with slightly different physiocochemical properties emerges. This could indicate that the spleen plays a relatively important role in the interferon response to Poly I:C. Splenectomy could be followed by the development of a compensatory cell population responsible for the production of interferon with slightly different molecular weight, isoelectric point and stability in urea.

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References

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